가토 두개골 결손 모델에서 Bioglass가 첨가된 불소화 수산화인회석의 골재생능력
Bone regeneration of the fluoridated hydroxyapatite and the bio-glass in the rabbit cranium defect model
안효준, 한세진, 김경욱,
소속 상세정보
안효준 ( Ahn Hyo-Joon ) - 단국대학교 치과대학 구강악안면외과학교실
한세진 ( Han Se-Jin ) - 단국대학교 치과대학 구강악안면외과학교실
김경욱 ( Kim Kyung-Wook ) - 단국대학교 치과대학 구강악안면외과학교실
KMID : 0355620110370050380
Abstract
Introduction:Hydroxyapatite (Ca10(PO4)6(OH)2, HA) is the main inorganic phase of human hard tissue that is used widely as the repair material for bones. When HA is applied to a bony defect, however, it can be encapsulated with fibrous tissue and float in the implanted area due to a lack of consolidation. Bioceramics as allogenic graft materials are added to HA to improve the rate and bone healing capacity. Fluoridated hydroxyapatite (Ca10(PO4)6(OH,F)2, FHA), where F- partially replaces the OH- in hydroxyapatite, is considered a good alternative material for bone repair owing to its solubility and biocompatibility.
Materials and Methods :This study was designed to determine the bone healing capacity of FHA newly produced as a nanoscale fiber in the laboratory. HA and FHA with bioglass was implanted in a rabbit cranium defect and the specimen was analysed histologically.
Results:1. At 4 weeks, fibrous connective tissue and little bone formation was observed around the materials of the experimental group I implanted HA and bioglass. Newly formed bone was observed around the materials in the experimental group II implanted FHA and bioglass. 2. At 8 weeks, the amount of newly formed and matured bone was higher in experimental group II than in experimental group I and the control group.
Conclusion:These results suggest that FHA and bioglass is a relatively favorable bone substitute with biocompatibility and better bone healing capacity than pure HA and bioglass.
키워드
Durapatite; Fluor-hydroxylapatite; Bioglass; Bone Substitutes
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